Bidirectional link seen for psychiatric disorders with chronic rhinosinusitis

According to a study, there is a bidirectional association between anxiety and depression and chronic rhinosinusitis (CRS) published online 12 sept. in JAMA Otolaryngology – Head and Neck Surgery.

Najm S. Khan, of Houston Methodist Hospital, and colleagues examined the bidirectional risk of anxiety and depression for patients with CRS in a retrospective cohort study of the National Institutes of Health All of Us database from January 1, 2008, to December 31, 2018. Two cohorts of adults with and without CRS were included. Patients with CRS were propensity score matched (1:5) to patients without CRS on age, sex, race, and annual household income; the analyses included 5,622 patients with CRS and 28,110 controls.

The researchers found that patients with CRS were more likely to have anxiety (odds ratio, 4.39) and depression (odds ratio, 2.04) and were at greater risk of developing anxiety (hazard ratio). [HR]2.79) and depression (HR, 1.40) compared with controls. Compared with controls, patients with anxiety (HR, 2.37) and depression (HR, 1.59) had an increased risk of developing CRS.

“Physicians and health care providers who regularly treat patients with anxiety, depression, and chronic rhinosinusitis should be vigilant for these risks and screen patients accordingly,” the authors write.

Several authors reported ties to the biopharmaceutical and medical device industries.

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